Fig. 2: An iNKT-Lymphocyte Recognizing a Self Glycolipid Antigen Bound to a CD1d Molecule on a Dendritic Cell

1. Antigen-presenting dendritic cells engulf certain glycolipids from human cells (endogenous glycolipids).
2. The glycolipids are degrade into epitopes by lysosomes.
3. The glycolipid epitopes are then bound to CD1d molecules produced in the endoplasmic reticulum by the dendritic cell.
4. The glycolipid epitope/CD1d complexs are transported by the Golgi apparatus to the surface of the dendritic cell.
5. Here the glycolipid epitope can be presented to theTCR of iNKT cells to induce iNKT cell activation.

Illustration of An iNKT-Lymphocyte Recognizing a Self Glycolipid Antigen Bound to a CD1d Molecule on a Dendritic Cell .jpg by Gary E. Kaiser, Ph.D.
Professor of Microbiology, The Community College of Baltimore County, Catonsville Campus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at https://cwoer.ccbcmd.edu/science/microbiology/index_gos.html.

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Last updated: August, 2019
Please send comments and inquiries to Dr. Gary Kaiser